Ezpay(中国)

Rongwen Xi, Ph.D.

Investigator, NIBS, Beijing, China

Phone：010-80726688-8510

Fax： 010-80723249

E-mail：xirongwen@cjcasa.com

Education

Professional Experience

Research Description

Publications:

1.  Yang F*, Quan Z, Huang H, He M, Liu X, Cai T, and Xi R* (2019). Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing. Elife 2019 Jan 16;8. pii: e40806. doi: 10.7554/eLife.40806.

2.  Zhang W, Zhang X, Xue Z, Li Y, Ma Q, Ren X, Zhang J, Yang S, Yang L, Wu M, Ren M, Xi R, Wu Z, Liu JL, Matunis E, Dai J, Gao G (2018). Probing the Function of Metazoan Histones with a Systematic Library of H3 and H4 Mutants. Dev Ezpay(中国). pii: S1534-5807(18)31031-1. doi: 10.1016/j.devcel.2018.11.047.5807(18)31031-1

3.  Chen J, Xu N, Wang C, Huang P, Huang H, Jin Z, Yu Z, Cai T, Jiao R, Xi R* (2018). Transient Scute activation via a self-stimulatory loop directs enteroendocrine Ezpay(中国) pair specification from self-renewing intestinal stem Ezpay(中国)s. Nat Ezpay(中国) Biol. 20(2):152-161

4. Yin C, Xi R* (2018). A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem Ezpay(中国) Enteroendocrine Commitment in Drosophila. Stem Ezpay(中国) Reports. 9;10(1):43-57. doi: 10.1016/j.stemcr.2017.11.014.

5.  Huang C, Yang F, Zhang Z, Zhang J, Cai G, Li L, Zheng Y, Chen S, Xi R*, Zhu B* (2017). Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila. Nat Commun. 8(1):1649. doi: 10.1038/s41467-017-01897-3.

6.  Liu X, Wei W, Li X, Shen P, Ju D, Wang Z, Zhang R, Yang F, Chen C, Cao K, Zhu G, Chen H, Chen L, Sui J, Zhang E, Wu K, Wang F, Zhao L, Xi R* (2017). BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3. Gastroenterology. 2017 Aug 2. pii: S0016-5085(17)35976-0. doi: 10.1053/j.gastro.2017.07.044

7.  Li Y*, Pang Z, Huang H, Wang C, Cai T, Xi R* (2017). Transcription Factor Antagonism Controls Enteroendocrine Ezpay(中国) Specification from Intestinal Stem Ezpay(中国)s. Sci Rep. 20;7(1):988. doi: 10.1038/s41598-017-01138-z.

8.  Yang F, Xi R* (2017). Silencing transposable elements in the Drosophila germline. Ezpay(中国) Mol Life Sci. 74(3):435-448 Review.

9.  Chen J., Li J., Huang H. and Xi R*. (2016). Gene Expression Analysis of Sorted Ezpay(中国)s by RNA-seq in Drosophila Intestine. Bio-protocol 6(24): e2079. DOI: 10.21769/BioProtoc.2079

10.Li X, Yang F, Chen H, Deng B, Li X, Xi R* (2016). Control of germline stem Ezpay(中国) differentiation by polycomb and trithorax group genes in the niche microenvironment. Development. 143(19):3449-3458 pii: dev.137638.

11.Chen J, Xu N, Huang H, Cai T, Xi R* (2016). A feedback amplification loop between stem Ezpay(中国)s and their progeny promotes tissue regeneration and tumorigenesis. Elife. 5. pii: e14330. doi: 10.7554/eLife.14330

12.Wang C, Xi R* (2015). Keeping intestinal stem Ezpay(中国) differentiation on the Tramtrack. Fly (Austin). 14:0.

13.Hu Z, Hu Y, Liu X, Xi R, Zhang A, Liu D, Xie Q, Chen L (2015). Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor. Oncotarget. 6(31):31628-39

14.Wang C, Guo X, Dou K, Chen H, Xi R* (2015). Ttk69 acts as a master repressor of enteroendocrine Ezpay(中国) specification in Drosophila intestinal stem Ezpay(中国) lineages. Development 142(19):3321-31

15.Yang F, Zhao R, Fang X, Huang H, Xuan Y, Ma Y, Chen H, Cai T, Qi Y, Xi R* (2015). The RNA surveillance complex Pelo-Hbs1 is required for transposon silencing in the Drosophila germline. EMBO Rep. 16(8):965-74

16.Guo X, Chen J, Li Z and Xi R* (2015). Signaling Pathways Regulating Stem Ezpay(中国)s (Book Chapter) in R.C.Zhao (ed.), Stem Ezpay(中国)s: Basics and Clinical Translation, Translational Medicine Research 1. Shanghai Jiaotong University Press, Shanghai and Springer Science+Business Media Dordrecht.

17.Wang C, Guo X, Xi R* (2014). EGFR and Notch signaling respectively regulate proliferative activity and multiple Ezpay(中国) lineage differentiation of Drosophila gastric stem Ezpay(中国)s. Ezpay(中国) Research 24(5):610-27

18.Quan Z, Sun P, Lin G, Xi R* (2013). TSC1/2 regulates intestinal stem Ezpay(中国) maintenance and lineage differentiation via Rheb-TORC1-S6K but independent of nutrition status or Notch regulation. J Ezpay(中国) Sci. 126:3884-92

19.Wang C, Zhao R, Huang P, Yang F, Quan Z, Xu N, Xi R* (2013). APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression. Developmental Biology 378(2):122-40

20.Lin G, Zhang X, Ren J, Pang Z, Wang C, Xu N, Xi R* (2013). Integrin signaling is required for maintenance and proliferation of intestinal stem Ezpay(中国)s in Drosophila. Developmental Biology377(1):177-87

21.Wen P, Quan Z, Xi R* (2012). The biological function of the WD40 repeat-containing protein p55/Caf1 in Drosophila. Developmental Dynamics 241(3):455-64

22.Xu N, Wang SQ, Tan D, Gao Y, Lin G, Xi R* (2011). EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem Ezpay(中国)s. Developmental Biology 354(1):31-43

23.Su Y, Deng B, Xi R* (2011). Polycomb group genes in stem Ezpay(中国) self-renewal: a double-edged sword. Epigenetics. 6(1):16-9.

24.Sun P, Quan Z, Zhang, B, Wu T, Xi R* (2010). TSC1/2 tumour suppressor complex maintains Drosophila germline stem Ezpay(中国)s by preventing differentiation. Development 137(15):2461-9

25.Wen P, Sun P, Xi R* (2010). Stem Ezpay(中国) niche (book chapter) in “Regenerative Medicine – From Protocol to Patient”. The Springer Press.

26.Li X, Han Y, Xi R* (2010). Polycomb group genes Psc and Su(z)2 restrict follicle stem Ezpay(中国) self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling. Genes & Development 24(9):933-46.

27.Zhao R, Xi R* (2010). Stem Ezpay(中国) Competition for Niche Occupancy: Emerging Themes and Mechanisms. Stem Ezpay(中国) Rev. 6(3):345-50

28.Lin G, Xu N, Xi R* (2010). Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem Ezpay(中国)s. J Mol Ezpay(中国) Biol 2(1): 37-49.

29.Xi, R* (2009). Anchoring stem Ezpay(中国)s in the niche by Ezpay(中国) adhesion molecules. Ezpay(中国) Adh Migr 3(4): 396-401.

30.Lin G, Xi R* (2008) Intestinal stem Ezpay(中国), muscular niche and wingless signaling. Fly (Austin). 2(6): 310-2.

31.Lin G, Xu N, Xi R* (2008). Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem Ezpay(中国)s. Nature 455(7216):1119-23.

32.Zhao R, Xuan Y, Li X, Xi R* (2008). Age-related changes of germline stem Ezpay(中国) activity, niche signaling activity and egg production in Drosophila. Aging Ezpay(中国) 7(3):344-54.

33.Xi R, Xie T (2005). Stem Ezpay(中国) self-renewal controlled by chromatin remodeling factors. Science310(5753):1487-9.

34.Xi R, Doan C, Liu D, Xie T (2005). Pelota controls self-renewal of germline stem Ezpay(中国)s by repressing a bam-independent differentiation pathway. Development 132(24):5365-74.

35.Xi R, Kirrily D, Xie T (2005). Molecular mechanisms controlling germline and somatic stem Ezpay(中国)s: similarities and differences (review). Curr Opin Genet Dev. 15(4):381-7.

36.Rawlings JS, Rennebeck G, Harrison SM, Xi R, Harrison DA (2004). Two Drosophila Suppressors of Cytokine Signaling (SOCS) differentially regulate JAK and EGFR pathway activities. BMC Ezpay(中国) Biol. 15;5(1):38.

37.Song X, Wong, MD, Kawase E, Xi R, Ding BC, McCarthy J, Xie T (2004). BMP signaling from the niche directly represses the transcription of a differentiating gene, bag of marbles, in the germline stem Ezpay(中国)s of Drosophila ovary. Development 131(6):1353-64.

38.Xi R, McGregor JR, Harrison DA (2003). A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium. Developmental Ezpay(中国) 4(2):167-77.

39.McGregor JR, Xi R, Harrison DA (2002). JAK signaling is somatically required for follicle Ezpay(中国) differentiation in Drosophila. Development 129(3):705-17.