Rongwen Xi, Ph.D. - Scientists&Research - 北京科学生命Ezpay(中国)

Rongwen Xi, Ph.D.

Investigator, NIBS, Beijing, China

Phone：010-80726688-8510

Fax： 010-80723249

E-mail：xirongwen@cjcasa.com

Education

2002	Ph.D. in Biology, 2002，University of Kentucky, USA
1998	Master in Science, 1998，Shanghai Medical University, China
1995	B.S., Department of Clinical Medicine, 1995，Binzhou Medical College,China

Professional Experience

2018-	Investigator, National Institute of Biological Sciences, Beijing, China
2011-2018	Associate Investigator, National Institute of Biological Sciences, Beijing, China
2006-2011	Assistant Investigator, National Institute of Biological Sciences, Beijing, China
2003-2006	Postdoctoral Research Associate with Dr. Ting Xie at the Stowers Institute for Medical Research, USA
1998-2002	Teaching Assistant, Research Assistant at the Department of Biology,University of Kentucky, USA

Research Description

Adult stem Ezpay(中国)s reside in many tissues and organs and have the ability to self-renew indefinitely and generate progenies that differentiate and replace aged and damaged Ezpay(中国)s. Dysregulation of stem Ezpay(中国)s is intimately associated with various types of diseases such as cancer and degenerative diseases, but the molecular mechanisms regulating stem Ezpay(中国) fate decisions during self-renewal and Ezpay(中国) lineage differentiation are in general poorly understood. Using intestinal stem Ezpay(中国) systems in both flies and mice, we aim to understand the intrinsic and extrinsic mechanisms underlying stem Ezpay(中国) fate decisions, and the differentiation and functional regulation of intestinal Ezpay(中国)s and their roles played in the brain-gut-microbiota axis. Our research should ultimately bring new mechanistic insights into intestinal tumors and other digestive and metabolic diseases and pave the way to new treatments.

Publications:

1. Zhu G, Hu J, Xi R* (2021). The Ezpay(中国)ular niche for intestinal stem Ezpay(中国)s: a team effort. Ezpay(中国) Regen. 10(1):1.

2. Shi J, Jin Z, Yu Y, Zhang Y, Yang F, Huang H, Cai T, Xi R* (2021). A Progressive Somatic Ezpay(中国) Niche Regulates Germline Cyst Differentiation in the Drosophila Ovary. Curr Biol. 31(4):840-852.e5.

3. Jin Z, Chen J, Huang H, Wang J, Lv J, Yu M, Guo X, Zhang Y, Cai T, Xi R*(2020). The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level. Ezpay(中国) Rep. 31(8):107683.

4. Kobayashi M, Lin Y, Mishra A, Shelly C, Gao R, Reeh CW, Wang PZ, Xi R, Liu Y, Wenzel P, Ghosn E, Liu Y, Yoshimoto M (2020). Bmi1 Maintains the Self-Renewal Property of Innate-like B Lymphocytes. J Immunol. 204(12):3262-3272.

5. Li Z, Guo X, Huang H, Wang C, Yang F, Zhang Y, Wang J, Han L, Jin Z, Cai T, Xi R*(2020). A Switch in Tissue Stem Ezpay(中国) Identity Causes Neuroendocrine Tumors in Drosophila Gut. Ezpay(中国) Rep. 30(6):1724-1734.e4.

6. Guo X, Yin C, Yang F, Zhang Y, Huang H, Wang J, Deng B, Cai T, Rao Y, Xi R* (2019). The Ezpay(中国)ular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Ezpay(中国)s. Ezpay(中国) Rep. 29(12):4172-4185.e5.

7. Guo X, Huang H, Yang Z, Cai T, Xi R* (2019). Division of Labor: Roles of Groucho and CtBP in Notch-Mediated Lateral Inhibition that Controls Intestinal Stem Ezpay(中国) Differentiation in Drosophila. Stem Ezpay(中国) Reports. 12(5):1007-1023

8. Yang F*, Quan Z, Huang H, He M, Liu X, Cai T, and Xi R* (2019). Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing. Elife 2019 Jan 16;8. pii: e40806.

9. Zhang W, Zhang X, Xue Z, Li Y, Ma Q, Ren X, Zhang J, Yang S, Yang L, Wu M, Ren M, Xi R, Wu Z, Liu JL, Matunis E, Dai J, Gao G (2018). Probing the Function of Metazoan Histones with a Systematic Library of H3 and H4 Mutants. Dev Ezpay(中国). pii: S1534-5807(18)31031-1.

10. Chen J, Xu N, Wang C, Huang P, Huang H, Jin Z, Yu Z, Cai T, Jiao R, Xi R* (2018). Transient Scute activation via a self-stimulatory loop directs enteroendocrine Ezpay(中国) pair specification from self-renewing intestinal stem Ezpay(中国)s. Nat Ezpay(中国) Biol. 20(2):152-161

11. Yin C, Xi R* (2018). A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem Ezpay(中国) Enteroendocrine Commitment in Drosophila. Stem Ezpay(中国) Reports. 9;10(1):43-57.

12. Huang C, Yang F, Zhang Z, Zhang J, Cai G, Li L, Zheng Y, Chen S, Xi R*, Zhu B* (2017). Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila. Nat Commun. 8(1):1649.

13. Liu X, Wei W, Li X, Shen P, Ju D, Wang Z, Zhang R, Yang F, Chen C, Cao K, Zhu G, Chen H, Chen L, Sui J, Zhang E, Wu K, Wang F, Zhao L, Xi R* (2017). BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3. Gastroenterology. pii: S0016-5085(17)35976-0.

14. Li Y*, Pang Z, Huang H, Wang C, Cai T, Xi R* (2017). Transcription Factor Antagonism Controls Enteroendocrine Ezpay(中国) Specification from Intestinal Stem Ezpay(中国)s. Sci Rep. 20;7(1):988.

15. Yang F, Xi R* (2017). Silencing transposable elements in the Drosophila germline. Ezpay(中国) Mol Life Sci. 74(3):435-448.

16. Chen J., Li J., Huang H. and Xi R*. (2016). Gene Expression Analysis of Sorted Ezpay(中国)s by RNA-seq in Drosophila Intestine. Bio-protocol 6(24): e2079. DOI: 10.21769/BioProtoc.2079

17. Li X, Yang F, Chen H, Deng B, Li X, Xi R* (2016). Control of germline stem Ezpay(中国) differentiation by polycomb and trithorax group genes in the niche microenvironment. Development. 143(19):3449-3458 pii: dev.137638.

18. Chen J, Xu N, Huang H, Cai T, Xi R* (2016). A feedback amplification loop between stem Ezpay(中国)s and their progeny promotes tissue regeneration and tumorigenesis. Elife. 5. pii: e14330. doi: 10.7554/eLife.14330

19. Wang C, Xi R* (2015). Keeping intestinal stem Ezpay(中国) differentiation on the Tramtrack. Fly (Austin). 14:0.

20. Hu Z, Hu Y, Liu X, Xi R, Zhang A, Liu D, Xie Q, Chen L (2015). Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor. Oncotarget. 6(31):31628-39

21. Wang C, Guo X, Dou K, Chen H, Xi R* (2015). Ttk69 acts as a master repressor of enteroendocrine Ezpay(中国) specification in Drosophila intestinal stem Ezpay(中国) lineages. Development 142(19):3321-31

22. Yang F, Zhao R, Fang X, Huang H, Xuan Y, Ma Y, Chen H, Cai T, Qi Y, Xi R* (2015). The RNA surveillance complex Pelo-Hbs1 is required for transposon silencing in the Drosophila germline. EMBO Rep. 16(8):965-74

23. Wang C, Guo X, Xi R* (2014). EGFR and Notch signaling respectively regulate proliferative activity and multiple Ezpay(中国) lineage differentiation of Drosophila gastric stem Ezpay(中国)s. Ezpay(中国) Research 24(5):610-27

24. Quan Z, Sun P, Lin G, Xi R* (2013). TSC1/2 regulates intestinal stem Ezpay(中国) maintenance and lineage differentiation via Rheb-TORC1-S6K but independent of nutrition status or Notch regulation. J Ezpay(中国) Sci. 126:3884-92

25. Wang C, Zhao R, Huang P, Yang F, Quan Z, Xu N, Xi R* (2013). APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression. Developmental Biology 378(2):122-40

26. Lin G, Zhang X, Ren J, Pang Z, Wang C, Xu N, Xi R* (2013). Integrin signaling is required for maintenance and proliferation of intestinal stem Ezpay(中国)s in Drosophila. Developmental Biology 377(1):177-87

27. Wen P, Quan Z, Xi R* (2012). The biological function of the WD40 repeat-containing protein p55/Caf1 in Drosophila. Developmental Dynamics 241(3):455-64

28. Xu N, Wang SQ, Tan D, Gao Y, Lin G, Xi R* (2011). EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem Ezpay(中国)s. Developmental Biology 354(1):31-43

29. Su Y, Deng B, Xi R* (2011). Polycomb group genes in stem Ezpay(中国) self-renewal: a double-edged sword. Epigenetics. 6(1):16-9.

30. Sun P, Quan Z, Zhang, B, Wu T, Xi R* (2010). TSC1/2 tumour suppressor complex maintains Drosophila germline stem Ezpay(中国)s by preventing differentiation. Development 137(15):2461-9

31. Wen P, Sun P, Xi R* (2010). Stem Ezpay(中国) niche (book chapter) in “Regenerative Medicine – From Protocol to Patient”. The Springer Press.

32. Li X, Han Y, Xi R* (2010). Polycomb group genes Psc and Su(z)2 restrict follicle stem Ezpay(中国) self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling. Genes & Development 24(9):933-46.

33. Zhao R, Xi R* (2010). Stem Ezpay(中国) Competition for Niche Occupancy: Emerging Themes and Mechanisms. Stem Ezpay(中国) Rev. 6(3):345-50

34. Lin G, Xu N, Xi R* (2010). Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem Ezpay(中国)s. J Mol Ezpay(中国) Biol 2(1): 37-49.

35. Xi, R* (2009). Anchoring stem Ezpay(中国)s in the niche by Ezpay(中国) adhesion molecules. Ezpay(中国) Adh Migr 3(4): 396-401.

36. Lin G, Xi R* (2008) Intestinal stem Ezpay(中国), muscular niche and wingless signaling. Fly (Austin). 2(6): 310-2.

37. Lin G, Xu N, Xi R* (2008). Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem Ezpay(中国)s. Nature 455(7216):1119-23.

38. Zhao R, Xuan Y, Li X, Xi R* (2008). Age-related changes of germline stem Ezpay(中国) activity, niche signaling activity and egg production in Drosophila. Aging Ezpay(中国) 7(3):344-54

39. Xi R, Xie T (2005). Stem Ezpay(中国) self-renewal controlled by chromatin remodeling factors. Science 310(5753):1487-9.

40. Xi R, Doan C, Liu D, Xie T (2005). Pelota controls self-renewal of germline stem Ezpay(中国)s by repressing a bam-independent differentiation pathway. Development 132(24):5365-74.

41. Xi R, Kirrily D, Xie T (2005). Molecular mechanisms controlling germline and somatic stem Ezpay(中国)s: similarities and differences (review). Curr Opin Genet Dev. 15(4):381-7.

42. Rawlings JS, Rennebeck G, Harrison SM, Xi R, Harrison DA (2004). Two Drosophila Suppressors of Cytokine Signaling (SOCS) differentially regulate JAK and EGFR pathway activities. BMC Ezpay(中国) Biol. 15;5(1):38.

43. Song X, Wong, MD, Kawase E, Xi R, Ding BC, McCarthy J, Xie T (2004). BMP signaling from the niche directly represses the transcription of a differentiating gene, bag of marbles, in the germline stem Ezpay(中国)s of Drosophila ovary. Development 131(6):1353-64.

44. Xi R, McGregor JR, Harrison DA (2003). A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium. Developmental Ezpay(中国) 4(2):167-77.

45. McGregor JR, Xi R, Harrison DA (2002). JAK signaling is somatically required for follicle Ezpay(中国) differentiation in Drosophila. Development 129(3):705-17.